ct iqon images  (Philips Healthcare)

Journal: Bioactive Materials

Article Title: Nose-to-brain administration of cannabidiol-loaded polymeric micelles improves the core behavioral symptoms of autism spectrum disorder

doi: 10.1016/j.bioactmat.2026.03.019

Figure Lengend Snippet: Pharmacokinetics of 25% w/w CBD-loaded Pluronic® F127 polymeric micelles in ASD-like rats. (A) IVIS fluorescence micrographs of rat brains at different time points after i.n. administration of NIR-797-labeled CBD-loaded polymeric micelles, as imaged by IVIS (n = 4). (B) Fluorescence radiance intensity profiles in the brain of rat (n = 4). (C) IVIS fluorescence micrographs of rat olfactory bulbs 90 min after i.n. administration of NIR-797-labeled CBD-loaded polymeric micelles, as imaged by IVIS (n = 4). (D) CBD concentration in rat brains following the i.n. and oral administration of 25% w/w CBD-loaded Pluronic® F127 polymeric micelles and i.n. administration of CBD dissolved in propylene glycol. (E) CBD concentration in rat plasma following the i.n. and oral administration of 25% w/w CBD-loaded Pluronic® F127 polymeric micelles and i.n. administration of CBD dissolved in propylene glycol. In all the PK studies, the i.n. and oral CBD dose was 5 and 15 mg/kg, respectively. All data are presented as mean ± S.E. (n = 4).

Article Snippet: Imaging was performed using an IVIS® Spectrum CT system from PerkinElmer (Waltham, MA, USA).

Techniques: Drug discovery, Fluorescence, Labeling, Olfactory, Concentration Assay, Clinical Proteomics

Journal: Materials Today Bio

Article Title: Engineered bone-targeting Lycium barbarum L. -derived extracellular vesicle-like nanoparticles deliver miR167a-5p to regulate mitochondrial dynamics and metabolic reprogramming in alleviating osteoporosis

doi: 10.1016/j.mtbio.2026.103312

Figure Lengend Snippet: BT-LB-EVLPs ameliorate bone loss and improve bone strength in osteoporotic mice. (A) The experimental design and corresponding flowchart. (B) Representative micro-CT images of bone scan (n = 6). (C – G) Quantitative analysis of key bone microstructure parameters of femurs (n = 6). (H) Biomechanical properties analysis of femurs (n = 3). (I) H&E and Masson staining images of femurs (Scale bars, 50 μm and 200 μm) (n = 3). (J – L) Immunohistochemistry and semi-quantitative analysis of ALP and OCN expressions of femurs (n = 3). (M – N) WB images and quantitative analysis of RUNX2, ALP, and OPN (n = 3). (O) RT-qPCR of RUNX2 , ALP , and OPN mRNA levels. Data are presented as mean ± SD. Compared with the Sham group, # P < 0.05, ## P < 0.01. Compared with the OVX group, ∗ P < 0.05, ∗∗ P < 0.01.

Article Snippet: The harvested femoral specimens were scanned using a micro-CT imaging system (SkyScan, Knotich, Belgium), and 3D reconstructions were performed.

Techniques: Micro-CT, Staining, Immunohistochemistry, Quantitative RT-PCR

Journal: Materials Today Bio

Article Title: Engineered bone-targeting Lycium barbarum L. -derived extracellular vesicle-like nanoparticles deliver miR167a-5p to regulate mitochondrial dynamics and metabolic reprogramming in alleviating osteoporosis

doi: 10.1016/j.mtbio.2026.103312

Figure Lengend Snippet: BT-LB-EVLPs deliver miR167a-5p to exert anti-osteoporosis effects in vivo . (A) The experimental design and corresponding flowchart. (B) Representative micro-CT images of bone scan (n = 5). (C – H) Quantitative analysis of key bone microstructure parameters of femurs (n = 5). (I) H&E and Masson staining images of femurs (Scale bars, 50 μm and 200 μm) (n = 3). (J – L) Immunohistochemistry and semi-quantitative analysis of ALP and OCN expressions (n = 3). Data are presented as mean ± SD. Compared with the Sham group, # P < 0.05, ## P < 0.01. Compared with the OVX + Antagomir-NC group, ∗ P < 0.05, and ∗∗ P < 0.01. Compared with the OVX + Antagomir-NC + LB-EVLPs, & P < 0.05, && P < 0.01.

Article Snippet: The harvested femoral specimens were scanned using a micro-CT imaging system (SkyScan, Knotich, Belgium), and 3D reconstructions were performed.

Techniques: In Vivo, Micro-CT, Staining, Immunohistochemistry